Ⅱ型糖尿病血脂特点的观察

目的]观察Ⅱ型糖尿病患者血清中总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)、载脂蛋白AI(apoAl)、载脂蛋白B(apoB)的浓度与正常人是否有差异,以了解Ⅱ型糖尿病病人的脂类代谢是否有变化以及变化趋势对Ⅱ型糖尿病患者并发症的影响。方法]对50例临床已确诊的Ⅱ型糖尿病病人和10例健康人分别测定血清中的TC(CHOD-PAP)、TG(GPO-PAP)、HDL-C、LDL-C(直接法-液体双试剂)、apoAl、apoB(免疫比浊法).结果]部分Ⅱ型糖尿病患者脂类代谢出现异常,其中TC、TG、LDL-C、apoB水平升高,而HDL-C、apoAl降低,这些患者从临床资料看,多数并发大血管病变(冠心病、脑血管病变、肢体的动脉硬化等);部分Ⅱ型糠尿病患者血脂与正常对照组无显著性差异,临床资料显示,这些患者仅为单纯血糖升高,没有并发症出现.结论]Ⅱ型糖尿病患者的血脂代谢异常与并发症的关系密切.

On blood lipoid feature in Ⅱ DM

Objective] In order to analyse the relation between variation of blood lipoid level and chronic complication in noninsulin dependent diatetes mellitus, lipid is measured in EDM and normal controls. Including cholesterol, cholesterolester, trigceride, HDL-C, LDL-C, apolipoproteinAl and apolipoprotein. Methods] To measure blood lipid in 50 cases of EDM patients and 10 cases of healthy objects. Cholesterol and cholesterol ester were measured with CHOD-PAP method; triglyceride with GPO-PAP method HDL-C and LDL-C with direct method and, apolipoproteinAl and apoliproteinB with immuno assay. Results] There is lipoid metablie disturbance in some of EDM. The levels of TC TG HDL-C apoB are higher than normal and the levels of HDL-C ApoAl are lower than normal. Based on their disease cases, we can know most of than have chronis comlications (CHD vascular disease of brain, AS of legs and so on). There isn't clear difference between of blood lipoid some of IIDM and normal. Their disease cases show they are normal but GIu is high. Conclusion] There is correlation between lipoid netabolic disturbance and chronic complication in EDM.