| 新型免疫抑制抗生素霉酚酸酯的研究进展 |
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| 引用本文： | 徐蓉,胡辉,朱健.新型免疫抑制抗生素霉酚酸酯的研究进展[J].温州大学学报(社会科学版),2005,18(6):58-60,65. |
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| 作者姓名： | 徐蓉 胡辉 朱健 |
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| 作者单位： | 杭州华东制药股份有限公司,杭州310011 |
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| 摘 要： | 霉酚酸酯是一种新型免疫抑制作用的抗生素，在临床上广泛应用于各种器官移植，并具有多种新的临床应用价值。本文从霉酚酸酯的药效学、药代动力学、临床应用和霉酚酸生产等多角度进行综述，着重对霉酚酸酯生产中最关键的霉酚酸发酵的各种影响因素进行分析综合，最后展望了霉酚酸酯的发展趋势和研究前景。
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| 关 键 词： | 霉酚酸酯 免疫抑制剂 霉酚酸 |
| 文章编号： | 1008-309（2005）06-0058-11 |
| 收稿时间： | 05 10 2005 12:00AM |
| 修稿时间： | 2005-05-10 |
Recent Advance of Morpholinoethyl Ester of Mycophenolic Acid as a New Immunosuppressive Antibiotic |
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| XU Rong,HU Hui,ZHU Jian.Recent Advance of Morpholinoethyl Ester of Mycophenolic Acid as a New Immunosuppressive Antibiotic[J].Journal of Wenzhou University,2005,18(6):58-60,65. |
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| Authors: | XU Rong HU Hui ZHU Jian |
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| Institution: | Huadong Pharmaceutical Corp., Hangzhou, China 310013 |
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| Abstract: | Morpholinoethyl ester of mycophenolic acid (MMF) is a new imunosuppressive antibiotic withwide clinic application, especially for organ implantation. In the present communication, the pharmacology,pharmacokinetics, clinical applications and production of Morpholinoethyl Ester of Mycophenolic Acid arereviewed. Especially, the effects of fermentation conditions on the productivity of mycophenolic acid areintroduced in more details. Finally, the future profile of MMF's research and clinical interests is alsopresented. |
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| Keywords: | Morpholinoethyl ester of mycophenolic acid Immunosuppressive antibiotic Mycophenolic acid |
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