Hyperlipidemia in guinea pigs induced by chronic vitamin C deficiency |
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| Authors: | Praveen Sharma P K Sharma DSc J Pramod L K Kothari Rashmi Ranka Sushma Sharma |
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| Institution: | 1. Department of Biochemistry, Dr. S.N. Medical College, Jodhpur
2. Department of Biochemistry, J.L.N. Medical College, 305 001, Ajmer
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| Abstract: | Sixteen weeks of chronic vitamin C deficiency, induced in guinea pigs by restricted vitamin C intake, resulted in a marked
increase in the serum total LDL- and VLDL- cholesterol, triglycerides and total lipids. HDL-cholesterol decreased resulting
in a highly significant increase in LDL/HDL ratio. The results reconfirm that vitamin C deficiency causes changes in blood
lipid profile which could promote atherogenesis. |
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