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| 吗丙嗪对兔和人红细胞脂质过氧化的抑制 | |
| 引用本文： | 卢大用,陈恩鸿,曹静懿,金巍,田芳,丁健.吗丙嗪对兔和人红细胞脂质过氧化的抑制[J].上海大学学报(英文版),2003,7(3):301-304. |
| 作者姓名： | 卢大用 陈恩鸿 曹静懿 金巍 田芳 丁健 |
| 作者单位： | School of Life Sciences，Shanghai University，Shanghai 200436，China，Shanghai Institute of Materia Medica，Chinese Academy of Sciences，Shanghai 201203，China，Shanghai Institute of Materia Medica，Chinese Academy of Sciences，Shanghai 201203，China，School of Life Sciences，Shanghai University，Shanghai 200436，China，School of Life Sciences，Shanghai University，Shanghai 200436，China，Shanghai Institute of Materia Medica，Chinese Academy of Sciences，Shanghai 201203，China，Shanghai Institute of Materia Medica，Chinese Academy of Sciences，Shanghai 201203，China |
| 基金项目： | Science Foundation of Shanghai Higher Education (Grant No.97A49) |
| 摘 要： | Lipid peroxide (LPO) plays pivotal roles in the process and development of many diseases. In this work, we studied the inhibitory effect of probimane (Pro), a Chinese anticancer agent, on erythrocyte LPO and the interaction of Pro with sialic acids (sia). Malondialdehyde (MDA) of erythrocytes activated by hydrogen peroxide was measured. Pro was found to inhibit the product of LPO induced by hydrogen peroxide in a non-enzyme system of both rabbit and human erythrocytes in the absence of doxorubicin. Sia were |
| 关 键 词： | 吗丙嗪 兔 人 红细胞 脂质过氧化 抑制作用 自由基 抗癌剂 |
| 收稿时间： | 19 September 2002 |
Inhibition of probimane on lipid peroxidation of rabbit and human erythrocytes |
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| Lu?Da-Yong,Chen?En-Hong,Cao?Jing-Yi,Jing?Wei,Tian?Fang,Ding?Jian.Inhibition of probimane on lipid peroxidation of rabbit and human erythrocytes[J].Journal of Shanghai University(English Edition),2003,7(3):301-304. | |
| Authors: | Lu Da-Yong Chen En-Hong Cao Jing-Yi Jing Wei Tian Fang Ding Jian |
| Institution: | 1. School of Life Sciences, Shanghai University, Shanghai 200436, China;Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China 2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China 3. School of Life Sciences, Shanghai University, Shanghai 200436, China |
| Abstract: | Lipid peroxide (LPO) plays pivotal roles in the process and development of many diseases. In this work, we studied the inhibitory effect of probimane (Pro), a Chinese anticancer agent, on erythrocyte LPO and the interaction of Pro with sialic acids (sia). Malondialdehyde (MDA) of erythrocytes activated by hydrogen peroxide was measured. Pro was found to inhibit the product of LPO induced by hydrogen peroxide in a non-enzyme system of both rabbit and human erythrocytes in the absence of doxorubicin. Sia were found to enhance LPO production and the activity of N-glycolylneuraminic acid (NeuGc) was about 5 times higher than that of N-acetylneuraminic acid (5AcNeu) at equivalent concentrations. Pro inhibited the increased LPO production induced by sia and the activity of Pro against LPO with 5AcNeu was almost twofold higher than that of Pro alone. It suggests that Pro be an inhibitor of LPO (free radicals) and as a functional modulator of sia in body. |
| Keywords: | probimane free radicals Lipoperoxidation anticancer agent neuraminic acid (sialic acid) neoplasm metastasis |
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