慢性肾功能衰竭患者血浆脂蛋白(a)与纤溶活性的相关性

目的:研究慢性肾功能衰竭患者血浆脂蛋白(a)与纤溶活性的关系.方法:应用酶联免疫吸附法分别测定58例慢性肾功能衰竭患者及51名健康对照者的血浆脂蛋白(a)浓度,并以底物显色法测定其组织型纤溶酶原激活剂(tPA)及其抑制物(PAI)活性.结果:慢性肾功能衰竭患者血浆脂蛋白(a)浓度和PAI活性明显升高,tPA活性明显降低;脂蛋白(a)浓度与血浆尿素氮水平、PAI活性均呈正相关;脂蛋白(a)浓度与tPA活性呈负相关.结论:肾功能对血浆脂蛋白(a)浓度起一定的调节作用,脂蛋白(a)水平的升高与纤溶活性低下有关.

Relationship between Plasma Lp(a) Levels and Fibrinolytic Activation of Patients with Chronic Renal Failure

Objective:To investigate the correlation between plasma lipoprotein(a) levels and fibrinolytic activation in patients with chronic renal failure.Methods:The plasma lipoprotein(a) concentrations were measured by enzyme linked immunosorbent assay in 58 patients with chronic renal failure and 51 healthy objects.Plasma activity levels of tissue type plasminogen activator(tPA) and plasminogen activator inhibitor(PAI) were determined by spectrophotometric assay respectively.Results:The plasma lipoprotein(a) concentrations and activity of PAI in chronic renal failure patients were significantly higher than those control group,however plasma activity of tPA in chronic renal failure patients was significantly lower than that of control group.The plasma lipoprotein(a) concentration was significantly positive correlated with plasma BUN concentration and activity of PAI,but it was significantly negative correlated with activity of tPA.Conclusion:It indicates that renal function may contribute to regulating plasma lipoprotein(a) levels,elevating lipoprotein(a) concentration and lowering fibrinolytic activation.