Subtypes of ADH2 gene in alcoholics |
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Authors: | P Chinnaswamy V Vijayalakshmi |
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Institution: | (1) Institute of Laboratory Medicine, Kovai Medical Center and Hospital Limited, 641 014 Coimbatore, Tamil Nadu, India |
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Abstract: | Alocholism is the multifactorial disease influenced by genetic environmental interaction and genetic variation of the genes
may be associated with alcohol dependence due to its modified function in behavioral and physiological responses. In the present
study, genetic variation was detected in the subtypes of gene, coding for the alcohol metabolizing enzyme Alcohol Dehydrogenase
2 (ADH2). Blood samples were collected from the alcoholic and non alcoholic subjects and genotyping was performed using PCR-RFLP
(Polymerase Chain Reaction-Restriction Fragment Length Polymorphism), analysis to determine genetic polymorphisms in the ADH2
gene subtypes. The three subtypes of ADH2 gene (ADH2.1, ADH2.2 and ADH2.3) were found in both alcoholics (Family History Positive
and Family History Negative) as well as non alcoholics. |
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Keywords: | Alcohol dehydrogenase 2 gene subtypes Familial alcoholics Non familial alcoholics |
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