Effect of low-dose omega-3 fatty acids substitution on blood pressure, hyperinsulinemia and dyslipidemia in Indians with essential hypertension: A pilot study |
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Authors: | A Bhise P V Krishnan R Aggarwal M Gaiha J Bhattacharjee |
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Institution: | (1) Department of Medicine, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi;(2) Department of Biochemistry, Lady Hardinge Medical College, New Delhi;(3) Department of Biochemistry, Lady Hardinge Medical College and Smt. Sucheta Kriplani Hospital, 110 001 New Delhi |
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Abstract: | The present study comprised 100 patients of essential hypertension who were screened for fasting hyperinsulinemia, which was
detected in 77% cases. Twenty such hyperinsulinemic cases were subjected to 4 weeks of dietary control phase followed by 6
weeks of omega-3 fatty acids substitution either 0.6 g/d (group 1) or 1.2 g/d (group 2)]. The mean basal fasting plasma insulin
levels were significantly higher (p<0.001) in patients of hypertension when compared to normal controls (126.51±80.36 and
19.35±12.61 μU/ml respectively). At the end of 4 weeks of diet control only, no significant change was observed in any parameter.
After substitution of omega-3 fatty acid, a significant reduction of fasting plasma insulin levels in both group 1 (29%) and
group 2 (22.8%) was observed (p<0.001). Significant reduction of systolic and diastolic blood pressure (16.4% and 25% respectively),
serum cholesterol, triglycerides and low density lipoprotein was also noted in both groups (p<0.001), while high density lipoprotein
increased by ∼8 mg% in both groups. Thus omega-3 fatty acid substituion in low dose along-with curtailment of dietary omega-6
fatty acid may be used as an adjunctive measure in the management of essential hypertension. |
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Keywords: | Omega-3 Fatty acids Hyperinsulinemia Essential hypertension |
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