| 特效止痛宁的镇痛作用及机理研究 |
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| 引用本文： | 许实波,项辉,王文武,宁淑琴,王维国. 特效止痛宁的镇痛作用及机理研究[J]. 中山大学学报论丛, 1994, 0(6) |
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| 作者姓名： | 许实波 项辉 王文武 宁淑琴 王维国 |
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| 作者单位： | 中山大学生命科学学院药理室(许实波，项辉)，辽宁辽阳第三制药厂(王文武，宁淑琴)，辽宁辽阳第三制药厂(王维国) |
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| 摘 要： | 特效止痛宁经小鼠肌肉注射测得LD_(50)为7.59±1.08ml/kg,按LD_(50)的1/5,1/10,1/20设置药效学试验高、中、低3个剂量组.特效止痛宁肌肉注射,能显著延长热板法小鼠痛反应时间,其镇痛效果可维持2h以上;高、中剂量组对电刺激兔齿髓致痛有显著止痛作用,使光辐射热至大鼠甩尾反应时间延长,对电刺激大鼠鼠尾致痛及钾离子皮下透入致痛等均有显著镇痛效果.其镇痛机理既在外周,也可通过中枢发挥镇痛作用.
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| 关 键 词： | 特效止痛宁 镇痛 镇痛机理 |
Study on Anagesa of Texiaozhitongning and Its Mechanism |
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| Xu Shibo Xiang Hui Wang Wenwu Ning Shouqin Wang Weiguo Section of Pharmacology,School of Life Sciences,Zhongshan University. Study on Anagesa of Texiaozhitongning and Its Mechanism[J]. Studies in Logic, 1994, 0(6) |
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| Authors: | Xu Shibo Xiang Hui Wang Wenwu Ning Shouqin Wang Weiguo Section of Pharmacology School of Life Sciences Zhongshan University |
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| Abstract: | Acute toxicity test on mice showe that LD50 of Texiaozhitongning im is 7. 59 1. 08 ml/kg. When three potency doses of 1/5, 1/10, 1/20 of LD50 were used. Texiaozhitongning decreases multiple pains: hot plate method of mice, rabbit dental medulla evoked by elactric stimulus, the flicking of rat cauda induced by radiation heat, rat cauda caused by electric stimulas, and K subcutaneous penetration in rats. The mechanism of anagesa is on central or peripheral nervous system. |
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| Keywords: | Texiaozhitongning analgesa mechanism of action |
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