| Combining cisplatin and a STING agonist into one molecule for metalloimmunotherapy of cancerOA |
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| 作者姓名： | Shuren Zhang Dongfan Song Wenhao Yu Ji Li Xiaoyu Wang Yachao Li Zihan Zhao Qi Xue Jing Zhao Jie P.Li Zijian Guo |
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| 作者单位： | 1. State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering,Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University;2. Department of Urology, Afflliated Drum Tower Hospital,Medical School,Nanjing University |
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| 基金项目： | financially supported by the National Key R&D Program of China (2019YFA09006600)；;the National Natural Science Foundation of China (22293050, 22293051,22293052, 21977048, 92053111, 92153303, 21731004, 91953201and 22107047)；;the Natural Science Foundation of Jiangsu Province (BK20202004)；;Fundamental Research Funds for the Central Universities (0205/14380225)；;the Postdoctoral Research Funding Program of Jiangsu Province (003503)； |
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| 摘 要： | Mounting evidence suggests that strategies combining DNA-damaging agents and stimulator of interferon genes(STING) agonists are promising cancer therapeutic regimens because they can amplify STING activation and remodel the immunosuppressive tumor microenvironment. However, a single molecular entity comprising both agents has not yet been developed. Herein, we designed two PtIV-MSA-2 conjugates(Ⅰand Ⅱ) containing the DNA-damaging chemotherapeutic drug cisplatin and the innate immuneactivating ST...
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