Effect of ocimum flavonoids as a radioprotector on the erythrocyte antioxidants in oral cancer |
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Authors: | K Reshma V Rao Ashalatha M Dinesh DM Vasudevan |
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Institution: | (1) Department of Biochemistry, Centre for Basic Sciences, Kasturba Medical College, 575 004 Mangalore;(2) Department of Biochemistry, Father Muller’s Medical College, Mangalore;(3) Department of Oncology, Amrita Institute of Medical Sciences, Elamakkara, Cochin;(4) Amritha Institute Of Medical Sciences, Elamakkara, Cochin |
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Abstract: | Flavonoids extracted from the leaves of Indian holy basil, Ocimum sanctum showed promising results as radioprotector in rodents.
Hence it was thought pertinent to analyze the antioxidants of erythrocytes in oral cancer patients who were concurrently treated
with radiation and ocimum flavonoids. Oral cancer patients consisted of 2 groups. Group A (n=17) received radiation alone
while Group B(n=17) received radiation and ocimum flavonoids(OF). Samples of heparinised blood were collected prior to treatment,
15 and 30 days respectively after treatment. Blood from normal healthy volunteers were taken as controls (n=25). Erythrocytes
were analyzed for the antioxidants viz. glutathione, glucose 6 phosphate dehydrogenase, glutathione peroxidase and superoxide
dismutase by the standard methods. Results of analysis indicated that erythrocytes from cancer patients (Group A and B) had
significantly high glutathione levels before as well as after treatment compared to controls. It was observed that Group B
which received OF showed a significant reduction in glutathione levels in comparison with Group A. All the other parameters
showed no statistical significant changes. Results of the study suggest that erythrocytes from cancer patients responded to
oxidative stress by elevating glutathione levels, while a decrease in glutathione levels observed in Group B, could be due
to the free radical scavenging effect of OF, sparing the glutathione. However OF did not seem to exert its effect on other
antioxidants of erythrocytes. |
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Keywords: | Radiotherapy Radioprotector Ocimum flavonoids antioxidants |
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