Genetic Polymorphisms Associated With Breast Cancer in Malaysian Cohort |
| |
| Authors: | Jagdish Kaur Chahil Khamsigan Munretnam Nurulhafizah Samsudin Say Hean Lye Nikman Adli Nor Hashim Nurul Hanis Ramzi Sharmila Velapasamy Ler Lian Wee Livy Alex |
| |
| Affiliation: | Molecular Research and Services Laboratory, INFOVALLEY® Life Sciences Sdn. Bhd., Unit 101, Level 1, Block B, Mines Waterfront Business Park, No. 3, Jalan Tasik, 43300 MINES Resort City, Selangor Malaysia |
| |
| Abstract: | Genome-wide association studies have discovered multiple single nucleotide polymorphisms (SNPs) associated with the risk of common diseases. The objective of this study was to demonstrate the replication of previously published SNPs that showed statistical significance for breast cancer in the Malaysian population. In this case–control study, 80 subjects for each group were recruited from various hospitals in Malaysia. A total of 768 SNPs were genotyped and analyzed to distinguish risk and protective alleles. A total of three SNPs were found to be associated with increased risk of breast cancer while six SNPs showed protective effect. All nine were statistically significant SNPs (p ≤ 0.01), five SNPs from previous studies were successfully replicated in our study. Significant modifiable (diet) and non-modifiable (family history of breast cancer in first degree relative) risk factors were also observed. We identified nine SNPs from this study to be either conferring susceptibility or protection to breast cancer which may serve as potential markers in risk prediction.Electronic supplementary materialThe online version of this article (doi:10.1007/s12291-013-0414-0) contains supplementary material, which is available to authorized users. |
| |
| Keywords: | Breast cancer, SNP, Association, Risk prediction model, Case– control study |
|
|
