| A New Potent Inhibitor of Thrombin from the Leech Haemendipsa Yanyuanensis |
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| 作者姓名： | ZHAO Rong le College of Life Sciences Beijing Normal University Beijing China |
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| 作者单位： | ZHAO Rong le College of Life Sciences，Beijing Normal University，Beijing 100875，China |
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| 基金项目： | itachiChemicalResearchCenter Inc .U .S .A . |
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| 摘 要： | 1 Ｉｎｔｒｏｄｕｃｔｉｏｎ Ｔｈｒｏｍｂｕｓｄｉｓｅａｓｅｏｆｈｅａｒｔａｎｄｂｒａｉｎｂｌｏｏｄｖｅｓｓｅｌｈａｓｂｅｃｏｍｅａｋｉｌｌｅｒｏｆｍａｎ .Ｂｅｃａｕｓｅｏｆｔｈｅｓｉｄｅｅｆｆｅｃｔｓｏｆｈａｅｍｏｒｒｈａｇｅｏｒｔｈｅｓｈｏｒｔｈａｌｆ ｌｉｆｅｉｎｖｉｖｏ ,ｔｈｅｐｒｅ ｓｅｎｔａｎｔｉｃｏａｇｕｌａｎｔｄｒｕｇｓａｒｅｕｎｓａｔｉｓｆｉｅｄ ,ａｎｄｓｅａｒｃｈ ｉｎｇｆｏｒｎｅｗａｎｔｉｃｏａｇｕｌａｎｔｓｗｉｔｈｈｉｇｈｅｒｅｆｆｉｃｉｅｎｔａｎｄｍｏｒｅｓｔａｂｉｌｅｈａ…
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A New Potent Inhibitor of Thrombin from the Leech Haemendipsa Yanyuanensis |
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| ZHAO Rong le College of Life Sciences,Beijing Normal University,Beijing ,China.A New Potent Inhibitor of Thrombin from the Leech Haemendipsa Yanyuanensis[J].Journal of Shanghai University(English Edition),2001(1). |
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| Authors: | ZHAO Rong le College of Life Sciences Beijing Normal University Beijing China |
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| Institution: | ZHAO Rong le College of Life Sciences,Beijing Normal University,Beijing 100875,China |
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| Abstract: | Two components of anticoagulant protein were isolated from the leech Haemendipsa yanyuanensis by heparin agarose affinity chromatography and ultracentrifugation. The determination of anticoagulant activity and characterization analysis of the protein using the method of chromogenic substrate indicates that the anticoagulant protein is thrombin specific but not factor Xa specific. The results lay a foundation for the research of the anticoagulant mechanism and application of anticoagulant protein from H. yanyuanensis. |
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| Keywords: | Heamendipsa yanyuanensis anticoagulant protein thrombin factor Xa |
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