| 对羟基苯甘氨酸乙二醇酯盐酸盐的合成研究 |
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| 引用本文： | 孙百虎,李俊玲,尚平,于海军.对羟基苯甘氨酸乙二醇酯盐酸盐的合成研究[J].石家庄职业技术学院学报,2012,24(2):33-35. |
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| 作者姓名： | 孙百虎 李俊玲 尚平 于海军 |
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| 作者单位： | 1. 石家庄职业技术学院化学工程系,河北石家庄,050081
2. 石家庄环城生物化工厂研发部,河北石家庄,050081 |
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| 摘 要： | 合成对羟基苯甘氨酸乙二醇酯盐酸盐时,对羟基苯甘氨酸∶乙二醇∶氯化亚砜=1∶1.5∶1.5,在-10℃～0℃下酰化8 h,pH=6,将20 mL CH2Cl2直接加入作溶剂,20 mL CH2Cl2与氯化亚砜混合后滴加,滴加时间为2 h～3 h,反应总收率为96%.
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| 关 键 词： | 对羟基苯甘氨酸 酰化 乙二醇 对羟基苯甘氨酸乙二醇酯盐酸盐 |
The synthesis of the hydroxyphenylglycine glycol ester hydrochloride |
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| SUN Bai-hu,LI Jun-ling,SHANG Ping,YU Hai-jun.The synthesis of the hydroxyphenylglycine glycol ester hydrochloride[J].Journal of Shijiazhuang Vocational Technology Institute,2012,24(2):33-35. |
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| Authors: | SUN Bai-hu LI Jun-ling SHANG Ping YU Hai-jun |
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| Institution: | 1(1.Department of Chemistry,Shijiazhuang Vocational Technology Institute,Shijiazhuang,Hebei 050081,China; 2.Department of Research and Development,Shijiazhuang Huancheng Biochemical Plant,Shijiazhuang,Hebei 050081,China) |
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| Abstract: | This paper introduces the synthesis of the hydroxyphenylglycine glycol ester hydrochloride salt with a formula of hydroxyphenylglycine:ethylene glycol:thionyl chloride=1∶1.5∶1.5;-10-0℃,acylation 8h;PH=6;20ml CH2Cl2,added directly to the solvent,20ml CH2Cl2.It is mixed dropwise with thionyl chloride,with dropping time of 2-3h.The overall yield is 96%. |
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| Keywords: | hydroxyphenylglycine acylation glycol hydroxyphenylglycine glycol ester hydrochloride |
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