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| 芳基硒代4-脱氧-4''''-去甲表鬼臼毒素衍生物的合成及细胞毒性测定 | |
| 引用本文： | 米琴,曹长年,王彦广. 芳基硒代4-脱氧-4''''-去甲表鬼臼毒素衍生物的合成及细胞毒性测定[J]. 天水师范学院学报, 2005, 25(2): 42-44 |
| 作者姓名： | 米琴 曹长年 王彦广 |
| 作者单位： | 1. 青海师范大学,生物系,青海,西宁,810008 2. 青海大学,化工学院,青海,西宁,810016 3. 浙江大学,化学系,浙江,杭州,310027 |
| 摘 要： | 应用硼氢化钠还原法合成三个硒代鬼臼毒素衍生物。合成过程温和,无毒害,产率较高。通过红外吸收谱图、核磁谱图和质谱分析与目标产物一致。对卵巢癌细胞H O-8910具有一定的细胞毒作用,并与化合物浓度呈明显正相关。 |
| 关 键 词： | 硼氢化钠 合成 硒代鬼臼毒素 细胞毒性 |
| 文章编号： | 1371-1351(2005)02-0042-03 |
| 修稿时间： | 2004-12-26 |
Cytotoxicity Determination and Synthesis of Aryl Selenoyl-4-deoxy-4''''-demethylepipophyliotoxin |
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| MI Qin,CAO Chang-nian,WANG Yan-guang. Cytotoxicity Determination and Synthesis of Aryl Selenoyl-4-deoxy-4''''-demethylepipophyliotoxin[J]. Journal of Tianshui Normal University, 2005, 25(2): 42-44 | |
| Authors: | MI Qin CAO Chang-nian WANG Yan-guang |
| Affiliation: | MI Qin1,CAO Chang-nian2,WANG Yan-guang3 |
| Abstract: | Three derivatives of selenoylpodophyllotoxin were composed with the reduce method. The synthetic process is temperate; no toxicity and high rate of output. Derivatives are the same with target product through IR, 1HNMR, 13CNMR and EI-MS. Three derivatives have in vitro cytotoxicity on HO-8910 cell, and the cyto-toxicity is positively related to the monomer concentration. |
| Keywords: | sodiumborohydride synthesis se-lenoylpodophyllotoxin cytotoxicity |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |