首页 | 本学科首页   官方微博 | 高级检索  
     


Garlic Oil and Vitamin E Prevent the Adverse Effects of Lead Acetate and Ethanol Separately as well as in Combination in the Drinking Water of Rats
Authors:G. R. Sajitha  Regi Jose  A. Andrews  K. G. Ajantha  Paul Augustine  K. T. Augusti
Affiliation:(1) Department of Biochemistry, Sree Mookambika Institute of Medical Sciences, Kanyakumari Dist, Kulasekharam, 629161, TN, India;(2) Department of Community Medicine, Dr. SMCSI Medical College, Karakonam, Trivandrum, India;(3) Department of Medical Biochemistry, School of Medical Education, MG University Centre, Gandhi Nagar, Kottayam, 686 008, India;(4) Department of Surgical Oncology, Regional Cancer Center, Trivandrum, India;(5) Department of Biochemistry (Rtd), Kerala University, Kunnethedam, R1-JaiNagar, Medical College P.O., Thiruvananthapuram, 695011, Kerala, India;
Abstract:Daily feeding of drinking water containing lead acetate (160 mg/l) or 10% alcohol by volume or a combination of both to rats for a month produced certain deleterious effects through oxidative stress. Both heavy metal lead and alcohol are capable of doing such damages. The deleterious alterations observed were in the parameters of blood, serum and tissues, viz; Hb, Pb, proteins, lipids, lipid per oxidation, Vitamins C and E levels and enzyme activities of AST, ALT, and catalase. Simultaneous feeding of either of the two antioxidants garlic oil (GO) and vitamin E at equal doses of 100 mg/kg/day, to the rats counteracted the deleterious effects of the above two chemicals significantly. The maximum damage was brought about by feeding of drinking water containing both lead acetate and alcohol. The protective effects of GO and Vitamin E were not significantly different. The mechanism of actions of the Vitamin E and GO is probably due to their efficiency as detoxifying agents and antioxidants, to scavenging free radicals as well as an independent action of GO on the removal of lead salt as lead sulfide.
Keywords:Lead acetate   Alcohol   Garlic oil   Vitamin E   Antioxidant   Toxicity
本文献已被 PubMed SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号