细胞因子与类风湿关节炎生物治疗

类风湿关节炎（Ｒｈｅｕｍａｔｉｏｄ　Ａｒｔｈｒｉｔｉｓ，ＲＡ）是一种原因不明的自身免疫性疾病，致残率高，严重影响病人的生活质量和预期生命，因此一直是世界范围内研究热．近年来由于分子生物学及免疫学的发展，也使风湿病的研究有了很大进展 大量研究表明，细胞因子在ＲＡ免疫反应中起到了重要作用．由此而产生的细胞因子生物治疗不仅为ＲＡ的治疗开辟了新的途径同时也将成为２１世纪的发展趋势．

Cytokines and Biologic Therapy in Rheumatoid Arthritis

Rheumatoid Arthritis (RA) is an unclear reason auto-immunity disease, which can severely influence the life quality and expectation of patients with high frequency of disability. With the devel6pment in molecular biology and immunology, the research on Rheumatology has improved quickly in recent years. Accumulated data has showed that cytokines play an important role in RA. Therefore, biologic therapy with cytokines not only provides a new method for RA but also becomes development tendency in the 21 century.