|
|||||
|
|
Study of Serum Homocysteine, Folic Acid and Vitamin B12 in Patients with Preeclampsia |
|
| Authors: | Shahid A Mujawar Vinayak W Patil Rekha G Daver |
| Institution: | 1. Department of Biochemistry, Grant Medical College and Sir J.J. Group of Government Hospitals, Mumbai, 400008, Maharashtra, India 3. Flat No-30, 7th Floor, Swstik-4, Sir J.J. Hospital Campus, Byculla, Mumbai, 400008, Maharashtra, India 2. Department of Obstetrics and Gynecology, Grant Medical College and Sir J.J. Group of Government Hospitals, Mumbai, 400008, Maharashtra, India |
| Abstract: | The present study was carried out to evaluate the occurrence of association between homocysteine, folic acid and vitamin B(12) in patients with preeclampsia. Fifty preeclamptic patients from gynecology ward were studied for estimation of serum homocysteine, folic acid and vitamin B(12) over a period of October 2007 to June 2010. Serum homocysteine and folic acid, and vitamin B(12) were determined by means of Immulite 1000 analyzer. The statistical analysis of study group of preeclampsia compared with normotensive control group, showed significant alterations in serum homocysteine, folic acid and vitamin B(12) concentrations in preeclampsia. Inverse association between serum homocysteine and folic acid, and vitamin B(12) levels were observed in preeclampsia. The present study found hyperhomocysteinemia and deficiency of folic acid and vitamin B(12) along with increased blood pressure as a risk factor for cardiovascular disease (CVD) in preeclampsia. |
| Keywords: | Homocysteine Folic acid Vitamin B12 Preeclampsia |
| 本文献已被 PubMed SpringerLink 等数据库收录！ | |