| 药物中间体8-甲基喹啉的合成 |
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| 引用本文： | 汪美芳.药物中间体8-甲基喹啉的合成[J].黄山学院学报,2007,9(3):61-62. |
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| 作者姓名： | 汪美芳 |
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| 作者单位： | 皖南医学院,化学教研室,安徽,芜湖,241000 |
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| 摘 要： | 以邻硝基甲苯、邻甲基苯胺和甘油为原料,在浓硫酸催化的作用下制得8-甲基喹啉,先用水蒸气蒸馏进行初步纯化,再用氯化锌的稀盐酸溶液使之生成8-甲基喹啉锌盐沉淀,滤饼用稀氢氧化钠溶液溶解,后经萃取制得高纯度的8-甲基喹啉,纯度可达98．8％。
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| 关 键 词： | 8-甲基喹啉 药物中间体 合成 |
| 文章编号： | 1672-447X（2007）03-0061-02 |
| 修稿时间： | 2007-03-27 |
Synthesis of the Chemical Intermedoate 8-Methylquinoline |
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| Wang Meifang.Synthesis of the Chemical Intermedoate 8-Methylquinoline[J].Journal of Huangshan University,2007,9(3):61-62. |
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| Authors: | Wang Meifang |
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| Institution: | Department of chemistry, Wannan Medical College, Wuhu241000, China |
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| Abstract: | 8-metylquinoline was synthesezed from O-Toluidine,O-nitrotoluene and glycerine by heating under the catalysis of concentrated sulfuric acid.It's salt of Zinc was precipitated by the solution of Zinc chloride with hydroen chloride,then the prue 8-metylquinoline was produced by the dissolved of the pre- cipitated in dilyte sodium hydroxide and extraction,and purity was over 98.8%. |
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| Keywords: | 8-metylquinoline chemical intermedoate synthesis |
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