| 低剂量氯喹和酮替酚联合作用下疟原虫的超微结构研究 |
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| 引用本文： | 尤力群,倪兵,曹汉民,You Li-qun,NI Bing,CAO Han-min. 低剂量氯喹和酮替酚联合作用下疟原虫的超微结构研究[J]. 上海大学学报(英文版), 2000, 4(4) |
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| 作者姓名： | 尤力群 倪兵 曹汉民 You Li-qun NI Bing CAO Han-min |
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| 摘 要： | 1 Ｉｎｔｒｏｄｕｃｔｉｏｎ Ｔｈｅｗｉｄｅｓｐｒｅａｄｄｅｖｅｌｏｐｍｅｎｔｏｆｃｈｌｏｒｏｑｕｉｎｅｒｅｓｉｓ ｔａｎｔ (ＣＲ)ｓｔｒａｉｎｏｆｍａｌａｒｉａｈａｓｒｅｓｕｌｔｅｄｉｎｓｅａｒｃｈｉｎｇｆｏｒｎｅｗｅｆｆｅｃｔｉｖｅａｎｔｉ ｍａｌａｒｉａｄｒｕｇｓ[1～ 4 ] .Ａｎａｎｔｉ ａｓｔｈｍａａｎｄａｎｔｉ ｍａｌａｒｉａｄｒｕｇｋｅｔｏｔｉｆｅｎ (Ｋ)ｈａｓｂｅｅｎｐｒｏｖｅｄｔｏｓｈｏｗｓｔｒｏｎｇａｎｔｉ ｍａｌａｒｉａａｃｔｉｏｎｂｙＰａｎｅｔａｌ[5～ 7] .ＦｕｒｔｈｅｒｍｏｒｅＫｈ…
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Effects of Low Dose of Ketotifen and Chloroquine Combination on the Ultrastructure of Chloroquine Resistant Strain of Plasmodium Yoelii |
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| You Li-qun,NI Bing,CAO Han-min. Effects of Low Dose of Ketotifen and Chloroquine Combination on the Ultrastructure of Chloroquine Resistant Strain of Plasmodium Yoelii[J]. Journal of Shanghai University(English Edition), 2000, 4(4) |
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| Authors: | You Li-qun NI Bing CAO Han-min |
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| Abstract: | 46 inbred NIH mice were infected by chloroquine resistant strain of Plasmodium yoelii. The ultrastructure changes were observed under the administration of ketotifen(10mg· kg- 1· d- 1 ) and chloroquine( 10mg. kg-1 · d- 1 ) combination and one after another respectively. The effect of taking ketotifen and chloroquine combination showed that parasites died rapidly with a few of intermittent membranes and vacuoles. The effect of taking two kinds of drugs one after another showed that there were exceedingly rich membranes, concentric arrangement structures similar to rough endo-reticulum and conspiciously blocking of the formation of food vacuoles. |
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| Keywords: | ketotifen chloroquine plasmodium yoelii chloroquine resistant strain ultrastructure |
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