| A New potent Inhibitor of Thrombin from the Leech Haemendipsa Yanyuznensis |
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| 作者姓名： | ZHAOrong－le |
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| 作者单位： | CollegeofLifeSciences,BeijingNormalUniversity,Beijing100875,China |
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| 摘 要： | Two components of anticoagulant protein were isolated from the leech Haemendipsa yanyuanensis by heparin agarose affinity chromatography and ultracentrifugation,The determination of anticoagulant activity and characterization analysis of the protein using the method of chromogenic substrate indicates that the anticoagulant protein is thrombin-specific but not factor Xa-specific.The resylts lay a foundation for the research of the anticoaguklant mechanism and application of anticoagulant protein from H.yanguanensis.
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| 关 键 词： | 血栓 新抑制剂 反凝结蛋白质 |
| 收稿时间： | 8 July 1999 |
A new potent inhibitor of thrombin from the leech Haemendipsa yanyuanensis |
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| Rong-le Zhao.A New potent Inhibitor of Thrombin from the Leech Haemendipsa Yanyuznensis[J].Journal of Shanghai University(English Edition),2001,5(1):86-88. |
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| Authors: | Rong-le Zhao |
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| Institution: | (1) College of Life Sciences, Beijing Normal University, 100875 Beijing, China |
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| Abstract: | Two components of anticoagulant protein were isolated from the leech Haemendipsa yanyuanensis by heparin agarose affinity chromatography and ultracentrifugation. The determination of anticoagulant activity and characterization
analysis of the protein using the method of chromogenic substrate indicates that the anticoagulant protein is thrombin-specific
but not factor Xa-specific. The results lay a foundation for the research of the anticoagulant mechanism and application of
anticoagulant protein from H. yanyuanensis.
Supported by Hitachi Chemical Research Center, Inc., U.S.A. |
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| Keywords: | Heamendipsa yanyuanensis anticoagulant protein thrombin factor Xa |
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