| 肺炎衣原体的培养及对人脐带静脉内皮细胞的感染 |
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| 引用本文： | 章黎苹,黄元伟,朱建华.肺炎衣原体的培养及对人脐带静脉内皮细胞的感染[J].科技通报,2002,18(2):89-92. |
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| 作者姓名： | 章黎苹 黄元伟 朱建华 |
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| 作者单位： | 浙江大学医学院附属第一医院心内科,浙江,杭州,310003 |
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| 基金项目： | 浙江省自然科学基金资助项目 (397479) |
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| 摘 要： | 目的：研究肺炎衣原体的培养及其对人脐带静脉内皮细胞的感染。方法：以人喉表皮癌（HEP－2）细胞培养肺炎衣原体并感染人肺带静脉内皮细胞，光镜及电镜下观察感染情况并计包涵体数。结果：肺炎衣原体能在HEP－2细胞内培养并能感染人肺带静脉内皮细胞，感染后72h，包涵体数最多，96h后仍可见肺炎衣原体在人肺带静脉内皮细胞内存活。结论：肺炎衣原体能感染并存活于人肺带静脉内皮细胞，能导致动脉内膜感染。
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| 关 键 词： | 肺炎衣原体 HEP－2细胞 人脐带静脉内皮细胞 感染 |
| 文章编号： | 1001-7119(2002)02-0089-04 |
| 修稿时间： | 2001年9月15日 |
Replication of Chlamydia Pneumoniae in HEP-2 Cells and Human Endothelial Cells |
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| ZHANG Li-ping,HUANG Yuan-wei,ZHU Jian-hua.Replication of Chlamydia Pneumoniae in HEP-2 Cells and Human Endothelial Cells[J].Bulletin of Science and Technology,2002,18(2):89-92. |
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| Authors: | ZHANG Li-ping HUANG Yuan-wei ZHU Jian-hua |
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| Abstract: | Objective To investigate whether Chlamydia pneumoniae (C.pn)could infect of human umbilical vein endothelial cells(HUVE cells). Methods After cultured in HEP-2 cells,C.pn was infected of HUVE cells,the inclusions were observed by ectromicroscoper.Results C.pn was able to grow and multiply in HEP-2 cells,infect and live in HUVE cells. Conclusion The ability of C.pn to grow in HUVE cells suggests a role for C.pn as a localpathogenetic factor in vascular inflammatory alterations, including atherogenesis. |
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| Keywords: | Chlamydia pneumoniae HEP-2 cell human umbilical vein endothelial cell atherogenesis |
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