| 润神口服液急性毒性试验 |
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| 引用本文： | 翟登高,王爱兰,张从胜,胥彩林. 润神口服液急性毒性试验[J]. 河北北方学院学报(医学版), 2001, 0(1) |
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| 作者姓名： | 翟登高 王爱兰 张从胜 胥彩林 |
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| 作者单位： | 张家口医学院免疫学教研室 075029(翟登高，王爱兰，张从胜)，张家口医学院免疫学教研室 075029(胥彩林) |
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| 摘 要： | 目的:为了观测润神口服液对小鼠的急性毒性作用。方法:给小鼠腹腔注射润神口服液,持续观测5～6d,计数小鼠死亡率,按概率单位法目测该口服液LD_(50)半数致死量。结果:LD_(50)为42.17ml/kg体重。结论:润神口服液毒性非常低,而且部分毒性原因是由于门服液pH偏低,大剂量注射引起酸中毒引起的。实验小鼠脾脏明显增重,可能与免疫力增强有关,而且存活小鼠体力明显增加(P<0.05)。
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| 关 键 词： | 润神口服液 LD_(50) |
Acute Toxicity Test of Runshen Oral Liquid |
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| Zhai Denggao,Wang Ailan,Zhang Congsheng,et al. Acute Toxicity Test of Runshen Oral Liquid[J]. Journal of Hebei North University:Medical Edition, 2001, 0(1) |
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| Authors: | Zhai Denggao Wang Ailan Zhang Congsheng et al |
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| Affiliation: | Zhai Denggao,Wang Ailan,Zhang Congsheng,et al Department of Immunology,Zhangjiakou Medical College,075029 |
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| Abstract: | Objective: To observe acute toxicity of Runshen Oral Liquid in mice. Methods: Runshen Oral Liquid was injected into peritoneum cavity of mice. The mice were continuously observed for 5 - 6 days and the mortality was counted. The fifty percent lethal dose(LD50) was statistically calculated either. Results: The LD50 of Runshen oral liquid in mice was 42.17ml /kg weight. Conclusion: The toxicity of Runshen Oral Liquid was very slight. Moreover, this toxicity in mice is partly ascribed to acidosis caused by acidity of Runshen Oral Liquid . |
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| Keywords: | Runshen Oral Liquid LD50 |
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