| Solid Phase Peptide Synthesis of Fusukang for AIDS |
| |
| 作者姓名： | 甘一如 戴琦 张雪竹 高晨昊 |
| |
| 作者单位： | School of Chemical Engineering and Technology，School of Chemical Engineering and Technology，School of Chemical Engineering and Technology，School of Chemical Engineering and Technology Tianjin University，Tianjin 300072，China，Tianjin University，Tianjin 300072，China，Tianjin University，Tianjin 300072，China，Tianjin University，Tianjin 300072，China |
| |
| 摘 要： | Acquiredimmunodeficiencysyndrome (AIDS)iscausedbytheinfectionofhumanimmunodeficiencyvirus(HIV ) .Glycoproteingp4 1isfoundtobethekeytoHIV′sinfectiontocellT1] .Dr.ZhoudesignedapeptidenamedFusukangasanHIVmembranefusioninhibitoraccordingtothestructureofgp 4 1. Fusukangconsistsof 36aminoacidresidues,andissynthesizedbythemanualsolidphasepeptidesynthesistechnique2 ,3] inthisresearch .1 Materialsandmethod1.1 Materials 9 fluorenylmethoxycarbonyl(Fmoc)aminoacids ,Wangresin ,dicyclohe…
|
Solid Phase Peptide Synthesis of Fusukang for AIDS |
| |
| GAN Yi-ru,DAI Qi,ZHANG Xue-zhu,GAO Chen-hao.Solid Phase Peptide Synthesis of Fusukang for AIDS[J].Transactions of Tianjin University,2003,9(4). |
| |
| Authors: | GAN Yi-ru DAI Qi ZHANG Xue-zhu GAO Chen-hao |
| |
| Abstract: | A 36-residue peptide is designed to cure acquired immunodeficiency syndrome(AIDS), and is synthesized by the manual solid phase peptide synthesis technique. Different reaction conditions of the synthesis process were discussed. Stirring efficiency of mechanics and nitrogen was compared. The mechanical method displays a predominant performance. Although the coupling efficiencies of diisopropylcarbodiimide(DIC) and dicyclohexylcarbodiimide(DCC) are virtually identical, DIC offers several advantages over DCC in practice due to different physical characters. Wash conditions after deprotection and coupling were investigated to monitor washing efficiency. 0.369 2 g crude peptide was obtained. |
| |
| Keywords: | solid phase peptide synthesis stirring efficiency coupling reagent wash conditions |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
