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Human cytomegalovirus induces alteration of β-actin mRNA and microfilaments in human embryo fibroblast cells
引用本文:林茂芳,魏国庆,黄河,蔡真.Human cytomegalovirus induces alteration of β-actin mRNA and microfilaments in human embryo fibroblast cells[J].浙江大学学报(B卷英文版),2004(6).
作者姓名:林茂芳  魏国庆  黄河  蔡真
作者单位:Department of Hematology,First Affiliated Hospital,College of Medical Science,Zhejiang University,Department of Hematology,First Affiliated Hospital,College of Medical Science,Zhejiang University,Department of Hematology,First Affiliated Hospital,College of Medical Science,Zhejiang University,Department of Hematology,First Affiliated Hospital,College of Medical Science,Zhejiang University Hangzhou 310003,China,Hangzhou 310003,China,Hangzhou 310003,China,Hangzhou 310003,China
基金项目:Project (No. 001103058) supported by the Key Program of Science and Technology Bureau of Zhejiang Province,China
摘    要:INTRODUCTION It is known that human embryo fibroblast cellsare permissive for cytomegalovirus (CMV) repli-cation in vitro. Data have shown that CMV infec-tion causes a rapid, progressive disruption of thehost cell cytoskeleton (CSK); and that the disrup-tion correlates with actin depolymerization. Someexperts used whole-mount (3D) electron micros-copy to analyze the CSK of uninfected and CMV-infected human lung fibroblast cells; and foundwithin 2 min of CMV infection, localiz…

关 键 词:Cytomegalovirus    Human  embryo  fibroblast  cells    Infection    β-actin    Microfilament
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