Enhanced expression of HMG-Y proteins in proliferating tissues |
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Authors: | Dinesh Singh M R Rajeswari |
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Institution: | (1) Department of Biochemistry, All India Institute of Medical Sciences, 110029 New Delhi, India |
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Abstract: | The high mobility group (HMG) proteins I and Y are well characterised non-histone chromosomal proteins which bind to A-T rich
regions of DNA and regulate gene expression and/or DNA replication. A correlation has been demonstrated between the increased
expression of HMG-Y proteins and malignancy. However, it is not known whether the expression of HMGs particularly, the Y group,
is a function of proliferation rate. In the present study, we have used normal tissues of calf testes, thymus and liver. The
results show distinctly high expression of HMG-Y proteins in testes than in thymus and the expression was practically undetectable
in liver. The results suggest that even in normal tissues there is a direct correlation between the proliferation rate and
the expression of the HMG-Y proteins, which can partly explain its increased expression in cancer. |
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Keywords: | HMG-Y proteins Cancer Cell Proliferation |
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