| UFCI基因在乳腺细胞系中的表达分析 |
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| 引用本文： | 贺爱兰,张梦成,彭东海.UFCI基因在乳腺细胞系中的表达分析[J].娄底师专学报,2011(2):79-81. |
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| 作者姓名： | 贺爱兰 张梦成 彭东海 |
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| 作者单位： | [1]湖南人文科技学院生命科学系,湖南娄底417001 [2]湖南人文科技学院计算机系,湖南娄底417001 |
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| 基金项目： | 湖南省自然科学基金项目资助（09JJ6048）; 湖南省教育厅科学研究项目（08C457）; 湖南省大学生研究性学习和创新性实验计划项目资助 |
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| 摘 要： | 泛素结合酶UFC1是一个新鉴定的类似泛素结合酶E2的基因。目前,对UFC1的功能研究报道还比较少,有待更进一步的研究和探讨。采用半定量RT-PCR技术分别检测一系列的乳腺细胞系MCF7、HBL100、MDA-MB231和MDA-MB-453中UFC1基因的转录水平,结果显示,在正常的HBL100乳腺细胞系中的表达最高,而在乳腺癌细胞系MCF7,MDA-MB231,MDA-MB-453中的表达明显降低。UFC1在乳腺细胞系中的差异表达的结果为将UFC1作为新的靶分子引入乳腺癌的临床预防和治疗提供实验依据。
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| 关 键 词： | UFC1 泛素化 乳腺癌 |
Analysis on UFC1 Expression in Breast Cell Lines |
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| HE Ai-lan,ZHANG Meng-cheng,PENG Dong-hai.Analysis on UFC1 Expression in Breast Cell Lines[J].Journal of Loudi Teachers College,2011(2):79-81. |
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| Authors: | HE Ai-lan ZHANG Meng-cheng PENG Dong-hai |
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| Institution: | 1.Department of Life Science,Hunan Institute of Humanities,Science and Technology,Loudi 417001,China; 2.Department of Computer Science,Hunan Institute of Humanities,Science and Technology,Loudi 417001,China) |
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| Abstract: | Ubiquitin-fold modifier conjugating enzyme 1（UFC1） is a new identified gene,which is analogous to the E2 ubiquitin-conjugating enzyme.Now,the function of UFC1 is less reported to waiting for further study and discussion.The expression profile of UFC1 gene was analyzed in different breast cell lines MCF7,HBL100,MDA-MB231 and MDA-MB-453 by Semi-quantitative RT-PCR assay.And the results show that the expression level of UFC1 gene in normal breast cell HBL100 is higher than the one in breast cancer cell MCF7,MDA-MB231 and MDA-MB-453.The evidence suggested that UFC1 might be a new candidate target molecule for clinical prevention and treatment in the breast cancer. |
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| Keywords: | UFC1 ubiquitin breast cancer |
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