Effect of L(+)-tartrate on liver enzymes in rats fed with calculi producing diet

The influence of L(+)-tartrate on liver cell constituents were investigated, during experimental stone formation in rats. A significant increase in the liver glycollate oxidase activity was observed in the calculogenic group. Tartrate administration had a considerable lowering effect on the liver glycollate oxidase activity and it also lowered the urinary excretion pattern of oxalate. The rats fed with calculi producing diet also exhibited moderately enhanced LDH, (Na⁺, K⁺)—and (Ca²⁺)—ATPase activities. The activities of inorganic pyrophosphatase and aminotransferases were slightly reduced. Acid phosphatase activity was significantly reduced with tartrate treatment. The use of tartrate in urolithiasis as a prophylactic measure to prevent recurrence may be beneficial.