Effect of exogenous L-ornithine L-aspartate on ethanol induced testicular injury in Wistar rats |
| |
| Authors: | Maneesh Mailankot H Jayalekshmi Amit Chakrabarti D M Vasudevan |
| |
| Institution: | (1) Department of Biochemistry, Melaka Manipal Medical College, Manipal, 576 104, India;(2) Amrita School of Biotechnology, Amritapuri, 690 525, India;(3) Department of Pharmacology, Sikkim Manipal Institute of Medical Sciences, Gangtok, 737 102, India;(4) Department of Biochemistry, Amrita Institute of Medical Sciences, Cochin, 662 026, India |
| |
| Abstract: | To investigate reversibility of ethanol induced testicular injuries on treatment with L-ornithine-L-aspartate, male Wistar
rats were treated with ethanol (1.6g/kg b.wt/day) and L-ornithine- L-aspartate (200mg/kg b.wt/ day) for 4 weeks. L-ornithine-L-aspartate
effectively prevented the ethanol induced body and testes weight reduction; changes in testicular weight well correlated with
body weight. Drug exhibited an ability to counteract ethanol induced oxidative challenge as it effectively reduced testicular
TBARS and increased tissue ascorbic acid, GSH and activities of superoxide dismutase, catalase, GSH-Red and Se-GSH-Px. However
the drug didn’t show promising effect on inhibitory effect of ethanol on testicular D5, 3-beta and 17-beta HSD (hydroxy steroid
dehydrogenase). |
| |
| Keywords: | Ethanol Oxidative damage Testicular injury L-ornithine-L-aspartate treatment |
| 本文献已被 SpringerLink 等数据库收录！ |
|
