苦参碱的药物代谢动力学研究

给兔静脉注射苦参碱后,血药浓度——时间曲线呈双指数型,符合开放式二室模型,用“3P87”程序对数据进行药动学模型拟合,求得药动学参数为 T_(1/2α),1.37min;T_1/2β), T6.58min; CL,23.59ml /min/kg; Vd,2.61 L /kg 。大鼠口服苦参碱后,各组织中的药物含量依次为肾、肝、肺、脑、心及血;其48h 内尿、24h 内粪及12h 内胆汁中的原形药物累积排泄量分别占给药量的53.73%、0.36%及0.27%。兔静脉给药后,12h 内尿及胆汁中的原形药物累积排出量分别占给药量的9.39%及0.37%。

Study of Pharmacokinetics on Matrine

The pharmacokinetic study of matrine was carried out by means of color- imetry.Matrine was injected intravenously into rabbits and the curve of blood concentration vs time was described by using an open two-compartment model. The pharmacokinetie parameters wre A,62.57 ug/ml;B,14.22ug/ml;α, 0.5045min~(-1);β,0.00905min~(-1);T_(1/2α),1.37min;T_(1/2β),76.58min;Cl,23.59 ml/min/kg;Vc,0.52L/kg;Vd,2.61L/kg.The content of matrine in rats' each tissue after administered orally was in turn the kidney,liver,lung,brain, heart and blood.Matrine was given orally to rats.The cumulative quantity of excretion of unchange drugs was 53.73% of the total dose in urine in 48h, 0.36% infeces in 24h and 0.27% in bile in 12h,while administered intraveno- usly to rabbits,was 9.39% of the total dose in urine and 0.37% in bile in 12h respectively.