Serum arylsulfatase A assay in metachromatic leukodystrophy: An experience in a neuropsychiatric set-up |
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Authors: | Rita Christopher C. P. Narayanan G. R. Arunodaya K. Taranath Shetty |
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Affiliation: | 1. Department of Neurochemistry and Neurology, National Institute of Mental Health and Neurosciences, 560 029, Bangalore
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Abstract: | Metachromatic leukodystrophy is a lysosomal disease caused mainly by a deficiency of the enzyme arylsulfatase A. The assay of arylsulfatase A in the serum provides a fast and easy method for the confirmatory diagnosis of this disorder. Serum arylsulfatase A was estimated in 52 normal healthy control subjects and 269 patients with symptoms of cerebral white matter disease in order to diagnose and confirm metachromatic leukodystrophy. A total of eight cases of metachromatic leukodystrophy with a low serum arylsulfatase A was detected, of which three cases were of the late-infantile type, four cases the juvenile type and only one case the adult type. |
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