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Brain type natriuretic peptide (BNP)—A marker of new millennium in diagnosis of congestive heart failure
Authors:Arun Raizada  Suman Bhandari  Muzaiyan Ahmed Khan  Harsh Vardhan Singh  Sherin Thomas  Vikram Sarabhai  Neelima Singh  Naresh Trehan
Affiliation:(1) Department of Biochemistry, People's College of Dental Sciences & Research Centre, 462018 Bhopal;(2) Department of Pathology, Hindu Rao Hospital, 110007 Delhi;(3) Department of Biochemistry, G. R. Medical College, 474002 Gwalior;(4) Department of Clinical Biochemistry and Cardiology, Escorts Heart Insitute & Research Centre, 110025 New Delhi
Abstract:The burden of disease in patients with congestive heart failure is high. The future of BNP looks promising as it may be a better diagnostic tool for the diagnosis of CHF in developing countries in new millennium. Natriuretic peptide hormones, a family of vasoactive peptides with many favourable physiological properties, have emerged as important contenders for development of diagnostic tools and therapeutic agents in cardiovascular disease. Measurement of B-type natriuretic peptide has become as an easy-to-perform bedside test. The clinical and diagnostic significance of the measurement of plasma Nt-proBNP in the diseases of the cardiovascular system with particular emphasis on the assessment of patients with heart failure and their effects on predicting survival rate. The plasma levels of Nt-proBrain Natriuretic peptide responds more vigorously after myocardial infarction than those of other natriuretic peptides. This article is an attempt to give a short overview on the utility of BNP-blood levels for the diagnosis and treatment of heart failure
Keywords:Congestive heart failure  B-type Natriuretic peptide  Amino terminal pro brain natriuretic peptide  Left ventricular ejection fraction  Myocardial Infarction
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