Effects of garlic extract treatment in normal and streptozotocin diabetic rats infected with <Emphasis Type="Italic">Candida albicans</Emphasis> |
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Authors: | M Bokaeian A Nakhaee Bita Moodi A Farhangi Azim Akbarzadeh |
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Institution: | 1.Department of Laboratory Sciences, Faculty of Paramedical sciences,Zahedan University of Medical Sciences,Zahedan,Iran;2.Department of Biochemistry, Faculty of Medicine,Zahedan University of Medical Sciences,Zahedan,Iran;3.Department of Pilot Biotechnology,Pasteur institute of Iran,Tehran,Iran;4.Pilot Biotechnology Department,Pasteur Institute of Iran,Tehran,Iran |
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Abstract: | The anti-candidial effect of garlic extract (Allium sativum L.) was investigated in normal and streptozotocin-induced diabetic
rats. Diabetes was induced after a single intraperitoneal injection of streptozotocin (60 mg/kg). Rats were divided into six
groups with fifteen rats in each group: (1) Normal control rats (2) Control rats + C. albicans (3) Control rats + garlic extract
+ C. albicans (4) Diabetic control rats (5) Diabetic rats + C. albicans (6) Diabetic rats + garlic extract + C. albicans.
The concerned groups were inoculated with C.albicans on the 15 th day. At the end of one month experiment, fasted rats were
killed by cervical decapitation. Blood was collected for estimation of glucose and C. albicans concentrations were estimated
in liver and kidneys homogenates. A significant increase was observed in serum glucose levels in diabetic rats. A loss of
bodyweight, polydipsia and polyphagia were observed in diabetic rats. Administration of alcoholic extract of garlic (0.25
g/kg body weight) reduced the hyperglycemia, polydipsia, polyphagia and associated weight loss of streptozotocin-treated rats.
Administration of garlic extract significantly reduced C. albicans concentrations in liver and kidneys homogenates in infected
control and diabetic rats. It is concluded that garlic extract improves candidia infection in diabetic rats. |
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