A comparative study on the effects of diet and exercise,metformin and metformin+pioglitazone treatment on NIDDM patients |
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Authors: | K T Augusti Sunil N P Andrews Abraham Sajimon Thomas Varghese Chemmanam |
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Institution: | (1) Department of Medical Biochemistry, School of Medical Education, Kottayam;(2) Department of Physician, Medical Centre Hospital, Kottayam;(3) Dept. of Medical Biochemistry, Palayad Campus of Kannur University, 670661 Tellicherry |
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Abstract: | A comparative study on two groups of newly diagnosed nonobese and obese NIDDM patients who were 15 in each group and treated
by diet cum exercise and metfromin monotherapy respectively and a third group of 15 obese NIDDM patients whose hyperglycemia
was not first controlled by a combination therapy of metformin and sulfonylurea and therefore changed over to a different
combination therapy of metformin and ploglitazone, was carried out before and after a period of three months treatment. The
mild hyperglycemia in the 1st group and the moderate or severe hyperglycemia with accompanied disorders of serum enzymes such as AST, ALT, GGT and the
level of HBA10 observed with 2nd and 3rd groups of obese NIDDM patients were significantly ameliorated by the respective mode of treatments. Here the efficacies of
the three types of treatment are substantiated and further it specifically depicts the success with the choice of combination
therapy with metformin and pioglitazone in the third group of obese diabetics. |
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Keywords: | NIDDM patients Diet cum exercise Metformin Pioglitazone FBS Enzymes HbA10 |
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