| 氮酮对丹皮酚巴布剂体外透皮吸收的影响 |
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| 引用本文： | 刘龙云,朱影影,王成永.氮酮对丹皮酚巴布剂体外透皮吸收的影响[J].淮南职业技术学院学报,2013(5):93-96. |
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| 作者姓名： | 刘龙云 朱影影 王成永 |
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| 作者单位： | [1]安徽中医药大学,合肥230000 [2]淮南职业技术学院,安徽淮南232001 |
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| 摘 要： | 为研究不同浓度的氮酮对丹皮酚巴布剂体外透皮吸收的影响，采用改良Franz扩散池法，液相色谱外标法检测丹皮酚的透过率；在丹皮酚巴布剂基质的制作过程中，分别加入2％、3％、4％的氮酮，检测不同浓度的氮酮对丹皮酚体外透皮吸收的影响；与空白组对照，2％、3％、4％的氮酮对丹皮酚的体外透皮吸收均有显著影响（P ＜0．01，P ＜0．01，P ＜0．01），对丹皮酚透皮速率提高大小顺序为3％的氮酮＞2％的氮酮＞4％的氮酮；得出氮酮可作为丹皮酚巴布剂的透皮促进剂。
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| 关 键 词： | 丹皮酚 巴布剂 促进剂 透皮给药系统 |
Effect of Azone on Paeonol Poultice Percutaneous Absorption in Vitro |
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| Institution: | LIU Long-- yun1 , ZHU Ying-- ying2 , WANG (1. Anhui University of Traditional Chinese Medicine, Chen--yong1 Hefei Anhui 230000; 2. Huainan Vocational Technical College, Huainan Anhui 232001) |
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| Abstract: | Objective： to study the effects of different concentrations of azone on paeonol poultice per cutaneous absorption in vitro of mice. Methods. using the modified Franz diffusion pool and HPLC exter nal standard method to test the transmittance of paeonol. 2%, 3%, 4% azone were added in the produc tion process of paeonol poultice matrix respectively, for testing the effects of different concentrations of azone on paeonol poultice percutaneous absorption in vitro of mice. Results.. compared with normal control group, 2 %, 3 %, 4% azone increased paeonol poultice percutaneous absorption in vitro of mice significant ly （P 〈 0.01 ,P 〈 0.01, P 〈0.01）. Conclusion. Azone could be used as a accelerant of paeonol poultice percutaneous absorption. |
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| Keywords: | paeonol poultice accelerant transdermal drug delivery system |
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