| 趋化因子受体CCR5亲和短肽的活性分析 |
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| 引用本文： | 王芳宇,潘忠诚.趋化因子受体CCR5亲和短肽的活性分析[J].怀化学院学报,2006,25(2):61-64. |
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| 作者姓名： | 王芳宇 潘忠诚 |
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| 作者单位： | 1. 衡阳师范学院,生命科学系,湖南,衡阳,421008
2. 哈尔滨工程大学化工学院,环境工程系,黑龙江,哈尔滨,150001 |
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| 摘 要： | 趋化因子受体CCR5与许多人类免疫疾病有关,而CCR5功能的缺失似乎并不会对人体产生很大的影响·通过对CCR5亲和短肽(AFDWTFVPSLIL)的活性分析,发现该短肽能抑制RANTES与PBMCs的结合,也能降低PBMCs对RANTES的趋化作用,并且能抑制RANTES引起的胞内Ca2 的升高,初步认为该短肽可作为CCR5的拮抗剂而受到进一步研究·
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| 关 键 词： | 趋化因子受体5 亲和短肽 外周血单个核细胞 Ca2 流动 趋化作用 RANTES |
| 文章编号： | 1671-9743(2006)02-0061-04 |
| 收稿时间： | 01 29 2006 12:00AM |
| 修稿时间： | 2006年1月29日 |
Activity Analysis of Peptide Binding to Chemokine Receptor CCR5 |
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| WANG Fang-yu,PAN Zhong-cheng.Activity Analysis of Peptide Binding to Chemokine Receptor CCR5[J].Journal of Huaihua University,2006,25(2):61-64. |
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| Authors: | WANG Fang-yu PAN Zhong-cheng |
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| Institution: | 1. Department of Life Science, Hengyang Normal University, Hengyang, Hunan 421008 ; 2. Department of Environmental and Engineering, School of Chemical Engineering, Harbin Engineering University, Harbin, Heilongjiang 150001 |
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| Abstract: | CCR5 is found to be involved in a broad range of human immune disease and function defeat of CCR5 has not harmful influence to human body.The activity analysis of peptide binding to CCR5 was performed,the results indicated that peptide inhibit the binding of RANTES to PBMCs and suppress chemotactic activity of PBMCs toward RANTES and abrogat the RANTES-induced increase of intracellular Ca~ 2 level in PBMCs.So the peptide should be further studied as a CCR5 antagonist. |
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| Keywords: | CCR5 peptide PBMCs Ca~ 2 influx chemotaxis RANTES |
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