Study of enzyme activities in the descending part of the duodenum in patients of duodenal ulcer |
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Authors: | V L C Fernandes D K Bhasin S V Rana |
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Institution: | (1) Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, H.No. 137, Sector 15-A, 160015 Chandigarh, India;(2) Department of internal medicine, Postgraduate Institute of Medical Education and Research, H.No. 137, Sector 15-A, 160015 Chandigarh, India |
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Abstract: | The aim of this study was to measure the levels of lactase, sucrase, maltase, leucine amino peptidase and gamma-glutamyl transpeptidase
in duodenum of Indian patients with duodenal ulcer. The effect of duodenum inflammation on these brush border enzymes has
also been analysed in this study. Levels of lactase, sucrase, maltase, leucine amino peptidase and gamma-glutamyl transpeptidase
were assessed in duodenal biopsies of 20 patients of duodenal ulcer and 20 non-ulcer dyspepsia. The duodenal biopsy specimens
were also examined histopathologically for presence or absence of inflammation. There was no significant difference (p>0.05)
in the activity of above mentioned enzyme levels in both the groups. Only levels of gamma-glutamyl transpeptidase were significantly
decreased in patients of duodenal ulcer with duodenal inflammation. This study shows that only the levels of gamma-glutamyl
transpeptidase were significantly decreased in patients of duodenal ulcer with inflammation but no change in duodenal enzymes
due to duodenal ulcer as compared to non-ulcer dyspepsia. |
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Keywords: | Inflammation duodenal ulcer leucine aminopeptidase |
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