| 顶空气相色谱法检测血液中三氯乙烯及其代谢物 |
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| 引用本文： | 王路,芦世仲,吴懿祖. 顶空气相色谱法检测血液中三氯乙烯及其代谢物[J]. 兰州石化职业技术学院学报, 2010, 10(4): 1-3 |
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| 作者姓名： | 王路 芦世仲 吴懿祖 |
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| 作者单位： | 福建警官职业学院刑事执行系;福建省漳平市公安局;福州市公安局晋安分局; |
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| 摘 要： | 建立了顶空气相色谱、CP-WAX 52CB石英毛细管色谱柱程序升温分离、ECD检测器测定血液中三氯乙烯及其代谢物三氯乙酸的分析方法。在2～800ng/mL范围内,三氯乙烯线性相关系数r=0.9991,最低检测浓度为1ng/mL(S/N=3);在2～800ng/mL范围内,三氯乙酸线性相关系数r=0.9994,最低检测浓度为1ng/mL(S/N=3)。各添加水平样品回收率均在95%以上,日间和日内RSD均小于10%,适于法医毒物分析的需要。
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| 关 键 词： | 顶空气相色谱 三氯乙烯 三氯乙酸 |
Determination of Trichloroethylene and its major metabolites in Blood by GC Chromatographic Headspace Analysis with Electron Capture Detector |
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| WANG Lu,LU Shi-zhong,WU Yi-zu. Determination of Trichloroethylene and its major metabolites in Blood by GC Chromatographic Headspace Analysis with Electron Capture Detector[J]. Journal of Lanzhou Petrochemical Vocational College of Technology, 2010, 10(4): 1-3 |
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| Authors: | WANG Lu LU Shi-zhong WU Yi-zu |
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| Affiliation: | WANG Lu1,LU Shi-zhong2,WU Yi-zu3 (1.Fujian Police Officer Vocational College,Fuzhou 350001,China,2.Zhangping Police Station,Zhangping 363000,3.Fuzhou Police Station,China) |
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| Abstract: | A simple,rapid and sensitive method was built for the determination of Trichloroethylene and its major metabolites in blood by GC Chromatographic Headspace Analysis with Electron Capture Detector.The headspace extracts from blood were separated by a 0.25μm×0.32mm×15m CP-WAX 52CB capillary column. The calibration curves were linear for both trichloroethylene and trichloroacetic acid.The coefficients of variation for both intra-day and inter-day were less than 10% and the recoveries were better than 95% at various spiked levels.The validated method fully meets the requirement for trichloroethylene and trichloroacetic acid analysis in blood in forensic medicine. |
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| Keywords: | Trichloroethylene trichloroacetic GC Chromatographic Headspace Analysis |
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