Cytokine Gene Polymorphism in Idiopathic Nephrotic Syndrome Children |
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| Authors: | Tabrez Jafar Suraksha Agrawal Abbas Ali Mahdi Raj Kumar Sharma Shally Awasthi G G Agarwal |
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| Institution: | (1) Department of Medical Genetics, SGPGIMS, Lucknow, UP, India;(2) Department of Biochemistry, CSMMU, Chhatrapati Shahuji Maharaj Medical University (Formerly King George Medical University), Chowk, Lucknow, UP, 226003, India;(3) Department of Nephrology, SGPGIMS, Lucknow, UP, India;(4) Department of Pediatrics, CSMMU, Lucknow, UP, India;(5) Department of Statistics, Lucknow University, Lucknow, UP, India; |
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| Abstract: | The pathogenesis of idiopathic nephrotic syndrome is not completely understood. We postulate that cytokine gene polymorphisms
may influence susceptibility or clinical course in Idiopathic Nephrotic Syndrome. Polymorphisms of IL-4, IL-6, and TNF-α cytokines
were investigated in 150 children with Idiopathic Nephrotic Syndrome and 569 healthy controls by using polymerase chain reaction
and restriction fragment length polymorphism. On comparing patient with controls strong association were found for IL-6, TNF-α
and IL-4 at allelic level (IL-6-G174C (G vs. C): P = <0.001; OR = 6.33, TNF-α-G308A (G vs. A): P = <0.001; OR = 1.99, IL-4-C590T (C vs. T): P = 0.048; OR = 1.38). Further when SR group was compared with SS group significant association was found at genotypic level
in all the studied genetic polymorphisms. Studied cytokine gene polymorphisms may influence susceptibility to idiopathic nephrotic
syndrome and might affect steroid response in INS patients. |
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| Keywords: | Idiopathic nephrotic syndrome IL-6 IL-4 TNF-α PCR RFLP |
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