轻度认知障碍患者单位数加法的ERP早成分研究

目的研究轻度认知障碍患者单位数加法的心算效率及事件相关电位（ERP）早成分改变。方法被试者分为正常老年（对照）组和轻度认知障碍（MCI）组，每组16名，均为右利手。使用事件相关电位技术，采集单位数加法计算过程的脑电信号，比较两组行为数据和算式早成分（N1，P1，N170，P2）的波幅和潜伏期的差异。结果MCI组的反应时间长于对照组，差异有显著性（P〈0．01），正确率MCI组低于对照组，差异有显著性（P〈0．01）；MCI组与对照组比较，颞枕区N170以及额中央区P2潜伏期延长（P〈0．01），波幅增大（P〈0.05）-MCI组左侧颞枕区N170波幅（-1．70uV）低于正常组（-2．96uV），差异具有显著性（P〈0．01）；MCI组右侧颞枕区N170波幅（-3．85uV）高于对照纽（-0．75uV），差异具有显著性（P〈0．01）。结论MCI患者的单位数心算效率降低，计算的正确率降低，同时提示大脑在算式早期加工阶段出现异常。

Early Components of Event-related Potentials of Single-unit Number Addition to Mild Cognitive Impairment Patients

Objective To study mental calculation efficiency and early components changes of event-related potentials on singledigit number addition of mild cognitive impairment （MCI） patients. Methods Sixteen healthy old men and 16 mild cognitive impairment pa- tients served as subjects in this experiment. Behavioral data,mean amplitude and latency of early components of event-related potential（ N1, P1 ,N170,P2） were compared between the two groups. Results The reaction time of MCI group was significantly longer than that of control group（ P 〈0.01 ） ;The correct rate of MCI group was significantly lower than that of control group（ P 〈 0.01 ）. Compared with the control group,the latency prolonged and the amplitude increased of the N170 in temporal-occipital region and P2 in central-frontal region in MCI group, N170 was significantly lower in left temporal-occipital region and higher in right temporal-occipital region in MCI group. Conclusion Patients with MCI have the deficit in single-digit number addition. The mechanism of early arithmetic calculation processing in MCI patients may be different from normal people.