| 中枢神经兴奋药物莫达非尼的合成 |
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| 引用本文： | 李德鹏,史云争,张晓辉,黄秉奂,王爱玲. 中枢神经兴奋药物莫达非尼的合成[J]. 大连大学学报, 2012, 0(6): 89-92 |
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| 作者姓名： | 李德鹏 史云争 张晓辉 黄秉奂 王爱玲 |
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| 作者单位： | 大连大学环境与化学工程学院;大连大学辽宁省生物有机化学重点实验室 |
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| 摘 要： | 莫达非尼是一种新型的中枢神经精神兴奋药物,毒副作用小,Lafon公司首先报道了莫达非尼的合成路线。改进了莫达非尼合成路线,优化了合成工艺条件,大大地缩短了反应时间,反应条件温和,合成操作简便。主要产物用IR、MS、1H-NMR表征了结构。
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| 关 键 词： | 莫达非尼 莫达非尼酸 兴奋药物 |
Synthesis of Central Stimulant Drug: Modafinil |
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| LI De-peng,SHI Yun-zheng,ZHANG Xiao-hui,HUANG Bing-huan,WANG Ai-ling. Synthesis of Central Stimulant Drug: Modafinil[J]. Journal of Dalian University, 2012, 0(6): 89-92 |
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| Authors: | LI De-peng SHI Yun-zheng ZHANG Xiao-hui HUANG Bing-huan WANG Ai-ling |
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| Affiliation: | 1,2,*(1.College of Environment and Chemical Engineering,Dalian University,Dalian 116622,China;2.Liaoning Key Laboratory of Bio-Organic Chemistry,Dalian University,Dalian 116622,China) |
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| Abstract: | Modafinil is a novel central stimulant drug and relatively small in side effects. The synthetic route of Modafinil is firstly reported by Lafon. This paper improved synthetic route of modafinil, and optimized the synthetic conditions. The reaction time was greatly shortened, the reactions condition was mild and the operation of synthesis was simple in this paper. Key products are characterizated by IR, MS and 1H-NMR. |
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| Keywords: | modafinil 2-（diphenylmethanesulfinyl） acetic acid central stimulant drug |
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