Antioxidant effect ofPhyllanthus emblica fruits on healing of indomethacin induced gastric ulcer in rats |
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| Authors: | Pakrashi Anita Pandit Srikanta Bandyopadhyay Sandip K. Pakrashi Satyesh C. |
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| Affiliation: | (1) Department of Biochemistry, Indian Institute of Chemical Biology, 244B, Acharya J. C. Bose Road, 700 032 Kolkata;(2) University College of Medicine Dr. B. C. Roy Post Graduate Institute of Basic Medical Sciences, Calcutta University, 244B, Acharya J.C. Bose Road, 700 020 Kolkata |
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| Abstract: | Post-treatment of the indomethacin induced ulcerated rats at the optimal dose of 100 mg/kg body-wt. orally for 7 consecutive days with the lyophilized aqueous extract of the fruits ofPhyllanthus emblica L. syn.Emblica officinalis Gaertn. (Euphorbiaceae) exhibited highly significant (p<0.001) enhancement of secretion of catalase, reduced glutathione and decrease in malonyldialdehyde (MDA). Furthermore, the gross morphological observation and highly significant (p<0.001) decrease of ulcer index (81.43%) indicated healing effect of the extract on gastric ulcer. |
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| Keywords: | Antioxidant antiulcer healing Phyllanthus emblica |
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