| A large scale screen for genes (3rd chromosome) related to Wingless signaling pathway |
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| 作者姓名： | 林欣大 程家安 |
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| 作者单位： | Institute of Applied Entomology，Zhejiang University，Institute of Applied Entomology，Zhejiang University Hangzhou 310029，China)，Division of Developmental Biology，Cincinnati Childrens Hospital Medical Center，University of Cincinnati，Cincinnati，OH 45229，USA，Hangzhou 310029，China |
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| 基金项目： | Project (No.30230070) supported partially by the National Natural Science Foundation of China |
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| 摘 要： | INTRODUCTION The Wingless (Wg) signal transduction path-way is an essential pathway in animal development (Wodarz and Nusse, 1998; Siegfried and Perrimon, 1994). The Wg signaling pathway is evolutionarily conserved and involved in numerous developmental processes in both Drosophila and vertebrates. Ho-mologs of both Wg and their signaling components have been identified in vertebrates. The powerful genetics of Drosophila melanogaster provides great opportunity for dissecting the comp…
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A large scale screen for genes (3rd chromosome) related to Wingless signaling pathway |
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| LIN Xin-da ,CHENG Jia-an.A large scale screen for genes (3rd chromosome) related to Wingless signaling pathway[J].Journal of Zhejiang University Science,2004(2). |
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| Authors: | LIN Xin-da CHENG Jia-an |
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| Institution: | LIN Xin-da )1,2,CHENG Jia-an 1 |
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| Abstract: | A wing specific F1 genetic screen was carried out using the powerful Drosophila genetic system, combined with yeast FRT/FLP and GAL4/UAS system. Form the wing phenotypes and germline clone embryonic cuticle phenotypes ob-served in these mutant alleles, a number of mutant alleles of known or unknown genes were isolated. Among them, fifteen mutant alleles related to Wingless signal transduction were further isolated; the arm of these mutations located were deter-mined, and their location in the chromosome were roughly mapped. |
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| Keywords: | Drosophila Genetic screen Wingless signal transduction Mutant allele |
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