| Antiphospholipid syndrome:a survey of clinical characters in ten cases |
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| 作者姓名： | 陈李华 姜玲玲 厉有名 彭清璧 |
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| 作者单位： | Department of Internal Medicine，First Affiliated Hospital，College of Med icine，Zhejiang University，Department of Internal Medicine，First Affiliated Hospital，College of Med icine，Zhejiang University，Department of Internal Medicine，First Affiliated Hospital，College of Med icine，Zhejiang University，Department of Internal Medicine，First Affiliated Hospital，College of Med icine，Zhejiang University Hangzhou 310003，China，Hangzhou 310003，China，Hangzhou 310003，China，Hangzhou 310003，China |
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| 摘 要： | INTRODUCTIONAPSisthesumtotalthatcoversaseriesofclinicalmanifestations,causedbyantiphospho lipidantibodies (APL)associatedwithhabitualabortionorintrauterinefetaldeath ,arterialandvenousthrombus,thrombocytopeniaandhemo lyticanemia.APL ,acomplement fixingant…
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Antiphospholipid syndrome:a survey of clinical characters in ten cases |
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| CHEN Li-hua,JIANG Ling-ling,LI You-mingPENG Qing-bi.Antiphospholipid syndrome:a survey of clinical characters in ten cases[J].Journal of Zhejiang University Science,2003(5). |
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| Authors: | CHEN Li-hua JIANG Ling-ling LI You-mingPENG Qing-bi |
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| Abstract: | Objective: To gain further understanding of the antiphospholipid syndr ome(APS). Methods: Analysing clinical and laboratory data on ten cases of APS. R esults: Thrombocytopenia appeared in all cases. Venous thrombi of limbs appeared in five cases and neurological abnormalities in two cases. Renal impairments we re found in three cases. One case manifested left renal venous thrombi and the o ther two cases thrombotic microangiopathy. Budd-Chiari syndrome was found in on e case. One of the ten cases was catastrophic APS(CAPS) presented as acute diffus e swel ling,cyanosis,pain,ischemia and necrosis in fingers and limbs,recurrent shoc k,ascites,hepatic and respiratory dysfunction. Anticoagulants and corticosteroids could be effective for dealing with APS. It was critical to trea t catastrophic APS with anticoagulants or plasmapheresis as early as possible. C onclusions: APS shows variable manifestations for good prognosis,but catastroph ic APS has fatal risk. The main treatment for APS is the use of anticoagulants a nd immunosuppressives. |
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| Keywords: | Antiphospholipid syndrome(APS) Antiphospholipid an tibodies (APL) Thrombosis |
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