| Expression of matrix metalloproteinase-9 in nasopharyngeal carcinoma and association with Epstein-Barr virus infection |
| |
| 作者姓名： | 汤建国 李旋 陈萍 |
| |
| 作者单位： | Sir Run Run Shaw Hospital，School of Medicine，Zhejiang University，Hangzhou 310016，China，Sir Run Run Shaw Hospital，School of Medicine，Zhejiang University，Hangzhou 310016，China，Sir Run Run Shaw Hospital，School of Medicine，Zhejiang University，Hangzhou 310016，China |
| |
| 摘 要： | Objective: To evaluate the expression of matrix metalloproteinase-9 (MMP9) in nasopharyngeal carcinoma and the association between MMP9 and Epstein-Barr virus infection. Methods: The MMP9 expression was studied by immu-nohistochemical analysis; and Epstein-Barr virus encoded small nuclear mRNA-1(EBER-1) produced by in situ hybridization were examined in 41 nasopharyngeal carcinoma sections, and the relation between them, and the associations of MMP9 with clinical features were statistically analyzed. Results: Positive expression rate of MMP9 was 73.17%. The expression of MMP9 showed significant positive correlation with the expression of EBER-1 (γ0.483, P=0.001). There was significant association of MMP9 expression with lymph nodes metastasis and clinical stage (P<0.001), non-significant association with age, gender, pathological classification and T classification. Conclusions: The highly pronounced expression of MMP9 is associated with cervical lymph nodes metastasis. Epstein-Barr virus can enhance N
|
Expression of matrix metalIoproteinase-9 in nasopharyngeal carcinoma and association with Epstein-Barr virus infection |
| |
| TANG Jian-guo,LI Xuan,CHEN Ping.Expression of matrix metalloproteinase-9 in nasopharyngeal carcinoma and association with Epstein-Barr virus infection[J].Journal of Zhejiang University Science,2004(10). |
| |
| Authors: | TANG Jian-guo LI Xuan CHEN Ping |
| |
| Abstract: | |
| |
| Keywords: | Matrix metalloproteinase-9 EB virus Nasopharyngeal carcinoma |
| 本文献已被 CNKI 等数据库收录！ |
