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| Synthesis and Biological Evaluation of Novel N-Benzoxazolonyluracils as Protox-Inhibitor | |
| 作者姓名： | 侯仲轲 任叶果 雷满香 黄明智 宋健 陈立功 |
| 作者单位： | [1]SchoolofPharmaceuticalandTechnology,TianjinUniversity,Tianjin300072,China／／HunanResearchInstituteofChemicalIndustry,Changsha410007,China [2]HunanResearchInstituteofChemicalIndustry,Changsha410007,China [3]SchoolofPharmaceuticalandTechnology,TianjinUniversity,Tianjin300072,China |
| 基金项目： | SupportedbyHunanNaturalScienceFoundation(No. 02JJY2017)andNationalNaturalScienceFoundationofChina(No. 20372021). |
| 摘 要： | Protoporphyrinogen oxidase inhibitor has become the focus research field as herbicides.Seven novel N-benzoxazolonyluracils were obtained by cyclization of 6-aminobenzoxazolone derivatives with ethyl 3-dimethylcarbamoylamido-4,4,4-trifluorocrotonate and then methylation or amination, and the reaction yields were between 59%-86%. The chemical structures of the compounds were identified by Elemental Analysis, MS and ^1H NMR. Biological results indicate that some compounds exhibit excellent control of broadleaf weeds at post-emergence by low dosage 18.75 ga.i/ha, but are not effective for grass weeds below dosage 37.5 ga. i/ha. In addition, these compounds show no damage at high-dosage 150 ga. i/ha to wheat and corn, but are unsafe to dicotyledonous plants such as cole, soybean and sorghum even at lower dosage 18.75 ga. i/ha. |
| 关 键 词： | 合成 生物学评价 N-苯并噁唑酮基尿嘧啶 原卟啉原氧化酶抑制剂 植物生长调节剂 |
Synthesis and Biological Evaluation of Novel N-Benzoxazolonyluracils as Protox-Inhibitor |
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| HOU Zhongke,Ren Yeguo,LEI Manxiang,Huang Mingzhi,SONG Jian,Chen Ligong.Synthesis and Biological Evaluation of Novel N-Benzoxazolonyluracils as Protox-Inhibitor[J].Transactions of Tianjin University,2005,11(1):26-29. | |
| Authors: | HOU Zhongke Ren Yeguo LEI Manxiang Huang Mingzhi SONG Jian Chen Ligong |
| Institution: | 1. School of Pharmaceutical and Technology, Tianjin University, Tianjin 300072, China;Hunan Research Institute of Chemical Industry, Changsha 410007, China 2. Hunan Research Institute of Chemical Industry, Changsha 410007, China 3. School of Pharmaceutical and Technology, Tianjin University, Tianjin 300072, China |
| Abstract: | Protoporphyrinogen oxidase inhibitor has become the focus research field as herbicides.Seven novel N-benzoxazolonyluracils were obtained by cyclization of 6-aminobenzoxazolone derivatives with ethyl 3-dimethylcarbamoylamido-4,4,4-trifluorocrotonate and then methylation or amination, and the reaction yields were between 590%-860%. The chemical structures of the compounds were identified by Elemental Analysis, MS and 1H NMR. Biological results indicate that some compounds exhibit excellent control of broadleaf weeds at post-emergence by low dosage 18.75 ga.i/ha, but are not effective for grass weeds below dosage 37.5 ga.i/ha. In addition, these compounds show no damage at high-dosage 150 ga.i/ha to wheat and corn, but are unsafe to dicotyledonous plants such as cole, soybean and sorghum even at lower dosage 18.75 ga.i/ha. |
| Keywords: | N-benzoxazolonyluracil protox-inhibitor synthesis biological evaluation |
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