Lipid metabolism in tumour bearing mice treated withAeromonas L-asparaginase |
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Authors: | P J Benny G Muraleedhara Kurup K Sreejith |
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Institution: | (1) School of Biosciences, Mahatma Gandhi University, 686560 Kottayam, Kerala, India |
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Abstract: | The anticancerous drug isolated in our laboratory from estuarineAeromonas was characterised and is found to be an enzyme, L-asparaginase. The antileukaemic effect of this drug was studied in mice
by inducing leukaemia with Ehrlich ascites cell lines. It was compared with commercially available drug, Leunase, isolated
fromE. coli. The lipid profiles in mice during leukaemia and under treatment was studied. The decreased levels of cholesterol and increased
levels of triglycerides and phospholipids in serum, liver and kidney were observed in tumour bearing mice. Significant changes
in the above values were observed with enzyme therapy. It could bring some of the values to near normal level. L-asparaginase
fromAeromonas was found to be more effective. |
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Keywords: | Aeromonas L-Asparaginase Lipids Tumour |
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