| 牛磺酸对超速驱动后大鼠心脏的保护作用研究 |
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| 引用本文： | 李岩.牛磺酸对超速驱动后大鼠心脏的保护作用研究[J].西安体育学院学报,2007,24(1):71-74. |
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| 作者姓名： | 李岩 |
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| 作者单位： | 鲁东大学,体育学院,山东,烟台,264025 |
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| 摘 要： | 探讨牛磺酸(Taurine)对超速驱动致疲劳缺血心脏的影响。采用Langendorff灌流装置,对超速驱动的离体心脏施加不同浓度牛磺酸的灌流液,测定心脏恢复功能、心肌组织GSH-Px活性、MDA含量以及NO含量、心肌组织及线粒体中Ca2 。结果显示牛磺酸对缺血心脏具有明显的保护作用,表现为心脏功能恢复显著,心肌谷胱甘肽过氧化物酶活性增高,丙二醛含量降低,心肌组织和线粒体钙超载减轻,该表现呈剂量依赖性。
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| 关 键 词： | 牛磺酸 超速驱动 疲劳心脏 细胞保护 |
| 文章编号： | 1001-747X（2007）01-0071-04 |
| 修稿时间： | 2006-02-242006-04-20 |
Research on the Protective Function of Taurine to the Isolated Rat Hearts after Overdrive |
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| LI Yan.Research on the Protective Function of Taurine to the Isolated Rat Hearts after Overdrive[J].Journal of Xi'an Institute of Physical Education,2007,24(1):71-74. |
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| Authors: | LI Yan |
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| Institution: | PE School, Ludong University, Yantai 264025, China |
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| Abstract: | Taking isolated rat hearts as research objective,with the adoption of Langendorff perfu-sion device,taurine perfusion solution of varied concentration is exerted on the overdriven isolate-d hearts for the research of the influence of taurine towards fatigued blood-deficit hearts after overdrive.The cardiac restoration function,the GSH-Px activity of myocardium,the content of MDA and NO and the Ca2 in myocardium and mitochondrion are respectively determined.The results indicate that taurine possesses tangible protective effect on blood-deficit hearts with performances of a notable restoration of the cardiac function, the increase of the enzymatic activity of GSH-Px,the decrease of the content of MDA and the alleviation of the calcium over-loading in myocardium and mitochondrion with a dosage reliance. |
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| Keywords: | taurine overdrive fatigue heart cell protection |
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