Ischemia modified albumin: A novel marker for acute coronary syndrome |
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Authors: | R Chawla Navendu Goyal Rajneesh Calton Shweta Goyal |
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Institution: | (1) Department of Biochemistry, Christian Medical College, 141 008 Ludhiana;(2) Department of Cardiology, Christian Medical College, 141 008 Ludhiana |
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Abstract: | Early identification of patients with acute myocardial infarction is of prime importance due to the associated very high mortality.
Only 22% of the patients presenting at emergency cardiology care with chest pain have coronary disease. A number of biochemical
tests like CKMB and Troponin-T/I have been introduced for early detection of the coronary syndrome (ACS). Ischemia modified
albumin (IMA) has been recently introduced as a marker of myocardial ischemia. We estimated serum IMA in four sequential samples
from 25 patients admitted to ICCU. Twenty five healthy volunteers formed the control group from which the normal range was
derived. IMA was significantly raised in ischemia patients than in controls as well as compared to the patients who did not
have cardiac ischemia. IMA demonstrated good discrimination between the ischemic and the non-ischemic patients with an Odds
Ratio of 16.9 (6.29–46.87) than CKMB which showed an Odds Ratio of 2.07 (1.18–6.08). Sensitivity and specificity of IMA for
the detection of ACS was 78.0% and 82.7% compared to 58.0% and 60.0%, respectively for the CK-MB assay. The area under the
ROC curve of IMA for ischemic v/s non-ischemic patients was 0.834. IMA appears to be developing into a new and very potent
marker, of cardiac ischemia. |
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Keywords: | Ischemia Modified Albumin Albumin Cobalt Binding Cardiac Ischemia |
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