| E-钙粘素与大肠癌侵润转移的关系 |
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| 引用本文： | 陶雅军,邓兆滨,任欣.E-钙粘素与大肠癌侵润转移的关系[J].大连大学学报,2002,23(6):94-98. |
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| 作者姓名： | 陶雅军 邓兆滨 任欣 |
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| 作者单位： | 1. 大连大学医学院,辽宁,大连,116622
2. 大连大学附属医院,辽宁,大连,116021 |
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| 摘 要： | 目的]探讨E-钙粘素(E-Cad)表达与大肠癌发生发展及预后的关系.方法]采用S.P免疫组织化学染色技术,检测30例大肠腺瘤,60例大肠癌组织E-Cad的表达情况.结果]E-Cad的表达率在大肠腺瘤中为87.10％,显著高于大肠癌中的55.00％(P
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| 关 键 词： | E-钙粘素 大肠癌 恶性生物学行为 |
| 文章编号： | 1008-2395(2002)06-0094-05 |
| 修稿时间： | 2002年6月12日 |
Relationship of expression of E- cadherin to invasion and metastasis of colorectal cancer |
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| TAO Ya-jun,DENG Zhao-bin,REN Xin.Relationship of expression of E- cadherin to invasion and metastasis of colorectal cancer[J].Journal of Dalian University,2002,23(6):94-98. |
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| Authors: | TAO Ya-jun DENG Zhao-bin REN Xin |
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| Abstract: | Objective] To investingate the role of the expression of E-cadherin (E-Cad) in carcinogensis and progression of colorectal cancer(CRC). Methods] The E-Cad expression was studied immuneohistochemistrically in 30 specimens of colorectal adenoma and 60 specimens of CRC. Results] The expression rates of E-Cad was 87.10% in colorectal adenoma and 55.00% in CRC, the former was apparently higher than the later (P<0.05); The significant relationship was observed between low E-Cad expression and cellular dedifferentiation and poor prognosis and negative correlation to metastasis of lymph node and distant organs. Conclusions] The expression rate of E - Cad is positive correlation to differentiative degree and survive time and negative correlation to metastasis of lymph node and distant organs. The detection of expression about E-Cad may be helpful to judge the malignant behavier, metastasis and prognosis with colorectal carcinoma. |
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| Keywords: | colorectal cancer E-cadherin malignant behaviors |
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