| 糖生物学——破解基因组功能的必由之路 |
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| 引用本文： | 金城. 糖生物学——破解基因组功能的必由之路[J]. 中国科学院大学学报, 2001, 18(1): 66-75. DOI: 10.7523/j.issn.2095-6134.2001.1.011 |
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| 作者姓名： | 金城 |
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| 作者单位： | 中国科学院微生物研究所微生物资源国家重点实验室, 北京 100080 |
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| 基金项目： | 中国科学院知识创新工程重要学科方向项目 (kscx 2 3 0 2 0 1) |
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| 摘 要： | 介绍了糖生物学研究的意义和动态,包括糖链与糖结合蛋白识别介导的细胞黏附,糖链在新生肽链折叠过程中、在免疫系统中、在细胞信号传导中的作用,糖链与微生物感染、糖链代谢疾病、糖链的化学合成与分析,以及糖生物学研究的特点和发展趋势.
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| 关 键 词： | 糖链 糖生物学 糖组学 糖缀合物 |
| 收稿时间： | 2001-04-24 |
Glycobiology-Essential for Discovery of Gene's Function |
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| Jin Cheng. Glycobiology-Essential for Discovery of Gene's Function[J]. , 2001, 18(1): 66-75. DOI: 10.7523/j.issn.2095-6134.2001.1.011 |
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| Authors: | Jin Cheng |
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| Affiliation: | State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080 |
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| Abstract: | This paper overviews the significance, advances and future direction in the glycobiology field. Special emphasis is given to cell cell adhesion which is mediated by the interaction between carbohydrates and carbohydrates binding proteins (CBP). The roles of carbohydrates in the folding of nascent polypeptides, immune system, and cellular signal transductions are also reviewed. The scope also covers carbohydrates in infections, carbohydrates in diseases,and chemical synthesis/structural analysis of carbohydrates. Finally,the features and future directions of glycobiological research are pointed out by the author. |
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| Keywords: | carbohydrate glycobiology glycomics glycoconjugate |
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